Low Platelet Level May be a Predictor for Mortality in Adult Patients with Common Variable Immune Deficiency

Introduction: Common variable immunodeficiency (CVID) is the most common symptomatic in adults. We aimed to reveal mortality rates, causes of CVID patients as well demographic and clinical characteristics differences survived dead patients, effect platelet counts on these patients. Materials methods: The study group included 50 [(Female: 23 (46%), Male: 27 (54%)] with CVID, who were followed-up at regular basis for a period ten years (115.18 ± 80.74 months). Results: Diagnostic delay was 84 (0-360) months mean follow-up time 115.18 months. presenting complaints frequent recurrent infections pneumonia. Of patients; 30% had lymphopenia, 56% splenomegaly, 60% bronchiectasis. At diagnosis, serum IgG levels 1.72 (0.33 – 6.90) g/L switched memory B cell percentages 1.70 (0 52.0). overall survival rate during 88%. As result univariate Cox regression analysis, count determined be an independent risk factor (Hazard ratio, HR: 0.990, 95% confidence interval, CI: 981-0.999, p: 0.025). multivariate analysis; current age, BMI neutrophil/lymphocyte ratio not found predictors mortality. When classified according counts, patient platelets 207770/mm3 (log-rank: 0.013). pneumonia pneumonia-induced sepsis. Conclusion: Clinicians dealing this should remember that immune dysregulation low are factors they particularly closely.